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In a combined analysis of three trials with 1,119 participants, individuals with PAM variants responded less effectively to GLP-1 drugs and were less likely to reach target HbA1c levels, a measure of long-term blood sugar control

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Our survey found that over 75% of health plans and over 50% of employers are moderately or very concerned about off-label use, but awareness of how much current spend is off-label is notably lower: nearly half of employers and a quarter of health plans are unsure