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Future research should aim to validate our findings in larger and more diverse pediatric cohorts, and to explore potential differences in subgroups with varying severity of GHD or higher levels of injection-related anxiety

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These trials have shown reductions in heart failure symptoms and physical limitations and greater improvement in exercise function and have led to growing interest in new ways to address HFpEF, a condition with limited guideline direct medication therapy compared to heart failure with reduced ejection fraction (HFrEF)