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Compound 1 was isolated by silica gel column chromatography using a dichloromethane/methanol (DCM:MeOH = 60:1, V/V) eluent (yield: 80%)
Slowed gastric emptying commonly causes gastrointestinal side effects including nausea, diarrhoea, constipation, and vomiting, particularly during the first 48 weeks
The paradigm shift: Mirtazapine's appetite stimulation is textbook CB1 receptor activation in feeding centers
It also improves lipid profiles, lowers insulin levels, and enhances glucose metabolism and insulin sensitivity
Regular check-ins, dose adjustments, and ongoing monitoring ensure you're getting results, not just taking medication and hoping
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