The efficacy and safety of the new GLP-1 medicines continues to garner interest and will be discussed #ADA2024 Here is an updated safety-focused summary of the field and where it might be headed @DiabetesCareADA #T2D #obesity pic.twitter.com/rtEQYtHQG0 Daniel J Drucker (@DanielJDrucker) June 6, 2024 Investigational GLP-1 medicines in the clinic Late-stage investigational GLP-1 medicines for type 2 diabetes and obesity include new molecules like retatrutide and orforglipron, showing potential differentiation from semaglutide and tirzepatide through better tolerability, greater weight loss, Hb A 1c reduction, and targeted outcomes

Seek urgent medical attention (call 999, go to A&E, or contact NHS 111) if: Body odour changes are accompanied by a sweet, fruity breath smell , excessive thirst, frequent urination, fatigue, or confusion these could indicate diabetic ketoacidosis (DKA), a serious complication requiring immediate treatment You experience severe, persistent abdominal pain (especially radiating to the back) with or without vomiting, which could indicate pancreatitis You develop severe pain in the upper right abdomen , fever, or yellowing of the skin/eyes, which might suggest gallbladder problems Contact your GP promptly if: You notice unusual or foul-smelling discharge from injection sites, which might suggest infection Odour changes coincide with persistent gastrointestinal symptoms such as vomiting or diarrhoea that could lead to dehydration You develop unexplained fever, night sweats , or unintentional weight loss beyond what's expected with treatment You experience sudden changes in vision , particularly if you have pre-existing diabetic retinopathy The odour is accompanied by skin changes , rashes, or other new symptoms Arrange a routine appointment to discuss: Persistent body odour concerns that affect your quality of life or confidence, even if not medically serious Any side effects that make you consider stopping Ozempic, as your doctor may adjust your dose or suggest alternative management strategies Questions about whether your symptoms are normal or require investigation Your healthcare team can perform a comprehensive assessment including review of your diabetes control (HbA1c levels), kidney and liver function tests, and evaluation for other potential causes of odour changes such as thyroid disorders, infections, or medication interactions

SattarNLeeMMYKristensenSLBranchKRHPratoDKhurmiSet alCardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials
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S., Rose, L., Hansen, T., Zacho, J., & Pieber, T