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Although 50 M yielded similar results at later time points, that concentration was suboptimal for this particular application because it increased the experimental duration and because cells are influenced by toxic effects at 48 h, likely due to the prolonged DMSO exposure

These washout periods, which have been updated slightly since the 2022 List documents were published on 30 September to incorporate the latest scientific information, are highlighted in the revised version of the Summary of Major Modifications and Explanatory Note, and are based on the use of these medications according to the maximum manufacturers licensed doses

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These medications may be acting on the knee through three simultaneous routes: reducing mechanical stress, protecting joint tissue directly and alleviating the pain that drives surgical decision-making. F&B takeaway: Whats important here is the ripple effect, says Circanas Lyons Wyatt

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