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Any bacteria in the air or on the needle can enter the vial

Chelation therapy, including nonabsorbed agents, should be initiated at a low dose and then gradually titrated to recommended doses according to the individual's response, to avoid the patient's health deteriorating with metal redistribution, other physiological perturbations, or drug intolerance

By the end of the acclimation period, the BAC system was consistently achieving a 38% reduction in TOC, highlighting the importance of biofilm establishment for long-term system performance

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However, the specificity of these criteria has recently been questioned [74]