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Critical role of LSEC in post-hepatectomy liver regeneration and failure

Briefly, Mercury(II) ions present in the environment cross the microorganisms cellular membrane and are scavenged by MerA, a homo-dimeric enzyme which sandwiches the Hg 2+ between a pair of catalytically essential cysteine thiol groups, to make a protein-embedded mercury(II)-bis-thiolate

In other words, hepatic fibrosis is fibrous scarring of the liver in which excessive collagens build up along with the duration and extent of persistence of liver injury

10.1097/MAO.0b013e3182267e06 32 KapoorN.ShyamR.SinghA.ManiK.SharmaR.SelvamurthyW

IRF1 drives transferrin receptor expression, elevates intracellular Fe 2+ levels, and disrupts iron homeostasis, thereby promoting ferroptosis