Despite this difference in volume, Wegovy showed the strongest disproportionality signal for ischemic optic neuropathy (reporting odds ratio [OR]=74.89) compared with Novo Nordisk diabetic drug Ozempic (reporting OR=18.81)
Beyond pancreatic effects, GLP-1 slows gastric emptying, which moderates postprandial glucose excursions, and acts on central nervous system receptors to promote satiety and reduce appetite
If "stronger" means more familiar biology, a clearer bridge from an already-approved GLP-1 backbone, and a less radical product concept, CagriSema looks stronger
Users often share practical approaches, experimenting with dosing schedules to balance appetite control, side effects, and affordability
Phase 2 and 3 studies, such as randomized controlled trials, have shown that these agents significantly reduce liver fat content, improve liver enzyme profiles, and promote histological improvements in patients with MASLD and MASH (6, 46)