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Injection site reactions are purely a tirzepatide concern and have nothing to do with bupropion, but they are worth mentioning because injection site reaction treatment sometimes involves anti-inflammatory medications that could interact with other drugs in your regimen

Discuss with your prescriber before making any changes to your injection schedule

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GLP-1 Receptor Agonists in the Management of Type 2 Diabetes and Obesity

Knockdown of IL-10 receptor- or pharmacological inhibition of STAT3 activation abolished exenatide-induced -endorphin expression and its antiallodynic effects [63]