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Longer duration of diabetes is usually associated with a higher risk of developing neuropathy

Neuropata ptica isqumica anterior no artertica (NAION) Un estudio de cohorte con poblacin de referencia neuro-oftalmolgica (y pacientes con diabetes) muestra un mayor riesgo de NAION con semaglutida vs otros frmacos en diabetes ( HR 4,28 ) y en sobrepeso/obesidad ( HR 7,64 ) (28)

This release of secondary messenger molecules, such as IP3, might potentially stimulate the discharge of calcium ions (Ca2+) from the cells internal stores

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10.1046/j.1365-2249.2002.01873.x 25