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While monotherapy with 5ARIs has a minimal impact on prostate cancer, there is much interest with combining the well tolerated hormonal effects of 5AR inhibitors with other therapeutic modalities

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Introduction Diabetes mellitus (DM, abbreviations are defined in Table 1) is a major public health problem worldwide, which imposes heavy economic and medical burdens on patients and healthcare systems [1, 2]

The GLP-1 and GIP arms meanwhile drive insulin secretion and gastric-emptying delay in different tissues and on different timescales (PMID 39515565, PMID 41785010)

Gender difference in cardiovascular outcomes with SGLT-2 inhibitors and GLP-1 receptor agonist in type 2 diabetes: a systematic review and meta-analysis of cardio-vascular outcome trials