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Anxiolytic-like effect of pyridoxine in mice by elevated plus maze and light and dark box: evidence for the involvement of GABAergic and NO-sGC-cGMP pathway

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This story originally appeared in the October 2022 issue of Men's Health.

Common reported side effects include nausea, vomiting, diarrhea, constipation, abdominal pain, and decreased appetite

Notably, SCFAs act as critical signaling metabolites that activate G-proteincoupled receptors (GPCRs), thereby suppressing pro-inflammatory cytokine production and promoting regulatory T-cell expansion within the colonic mucosa (301)