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Discontinuation should be gradual Using semaglutide for a short period and quitting can sometimes cause you to regain some weight, an experience referred to as Ozempic rebound. This can also happen with other brands of semalgutide, like Wegovy

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In contrast, higher concentrations inhibit mitochondrial complex I, thereby reducing oxidative stress and delaying the opening of the mitochondrial permeability transition pore (mPTP), a key event in ischemia-reperfusion injury (Zilov et al., 2019)