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Although the carboxyl-molecules can be made to react directly with amines using EDC, the reaction is much more efficient with NHS because a stable intermediate is created

Typical Timeline: First few days: Appetite suppression begins as the medication takes effect Weeks 1-4: Reduced caloric intake leads to initial weight loss Weeks 5-12: Steady weight loss continues, with most patients seeing 5% body weight loss by week 12 3-6 months: Many patients achieve 10% or more total body weight loss Plateau Management: Some patients experience plateaus, which is normal

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doi: 10.1111/j.1476-5381.1987.tb11206.x

But for the Hims crowd, who stem from more of a tech and consumer health background, this truth was not that salient