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Veterans Affairs data found that adults with type 2 diabetes who stayed on GLP-1 drugs for three years had the greatest reduction in heart attack, stroke or death compared with those on sulfonylureas, an older class of medication, and that even brief periods of discontinuations or interruptions might progressively erode and could ultimately reverse this protection. A Reuters Health summary of the same work reported that patients who remained on GLP-1s continuously saw an 18 percent reduction in cardiovascular risk versus sulfonylureas, while stopping for as little as six months raised risk by four percent and two years off treatment raised risk by 22 percent, compared with continuous use

Oral medication still provides a practical alternative for individuals who prefer tablets and can maintain consistent dosing habits

If those muscles are not coordinating properly, no amount of fiber, water, or magnesium will produce a satisfying bowel movement

However, for patients who have already reached a healthy weight, microdosing may help maintain results while potentially providing ongoing metabolic benefits with fewer side effects

Eng, J., Kleinman, W