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Gradual increases prevent bloating and constipation

A study looking at weight, height and motor-social development up to 6 months of age in children of mothers taking metformin while breastfeeding showed normal development and no difference from formula-fed infants (203)

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This is important because it indicates that any increase in systemic GLP-1 levels (for example through medication) could potentially influence the amount that reaches the joint. Tue Wenzel Kragstrup, MD, PhD The next step (in this research) is to find out whether GLP-1-based drugs reach the joints in high enough concentrations to have biological effects there, Kragstrup continued

Here is helpful guidance about how much to drink in a day, along with a free water tracker