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This delay contrasts with tirzepatide, which is currently accessible in the United States and has recently obtained approval in Europe.217 Adverse Reactions and Safety of GLP-1RAs and GLP-1/GIP Dual Receptor Agonist GLP-1RAs and dual agonists targeting GLP-1 and GIP receptors have demonstrated considerable efficacy in the treatment of T2DM and obesity

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Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients

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