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Necrotizing fasciitis Unlike sepsis, which involves a systemic response, necrotizing fasciitis is a rapidly progressing and aggressive bacterial infection confined to the subcutaneous tissue and fascia

Important considerations include: neither peptide has received broad regulatory approval for routine therapeutic use in major jurisdictions

doi: 10.3389/fphar.2025.1689575 Received 20 August 2025 Revised 22 October 2025 Accepted 27 October 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Mamunur Rashid, University of Nebraska Medical Center, United States Reviewed by Franois Trottein, Institut Pasteur de Lille, France Yunlei Zhang, Nanjing Medical University, China Updates Copyright 2025 Ruan, Lin, Lin, Zhan, Zheng, Lin, Zhuang and Zeng

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An in vitro model composed of senescent Leydig cells was used