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Nausea affected up to about 29 percent of participants Diarrhea up to about 23 percent Vomiting up to about 13 percent in some studies Reports of sleep disturbance or insomnia were not prominent in the trial safety tables for Zepbound

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The chronic activation of the type I IFN pathway by oxidative stress contributes to the dysregulation of immune responses and the production of autoantibodies in SLE [146]

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