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Effect size is represented by the number of arrows, where 1 arrow corresponds to 11.49-fold difference, 2 arrows to a 1.51.99-fold difference, 3 arrows to a 22.99-fold difference, 4 arrows a 39.99-fold difference, and 5 arrows a difference of tenfold or more (Stuart et al., 2013)

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In this review, we will use these three groups of metabolites as examples to explore major advancements in understanding how cellular metabolism regulates CD4+ and CD8 + T cell subset differentiation and their responses to invading pathogens, cancers, and self-antigens

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