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Males with the TT genotype (homozygous for Leu variant) were reported to have the lowest GPx-1 activity (25), whereas genotype had no affect on GPx-1 activity level in females in this study

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Glutathione benefits from supplementation may come from an increase in L-cysteine when glutathione breaks down into its amino acids

Furthermore, ABX itself may introduce non-specific immunological effects, requiring stricter controls and depletion verification metrics to reduce confounding