why do people gain weight after stopping semaglutide Comes Roaring Back When You Stop (And How To Prevent It) Weight Gain After Stopping Semaglutide:

Both substances can independently cause hypoglycemia, and their combined use may amplify this effect

doi: 10.1210/jendso/bvab048.013

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Stratified by different indications For indication of obesity alone, AOMs resulted in 1.31 kg (95% CI 0.38 to 2.24, P = 0.006, I 2 = 73%) weight regain compared with control groups

Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial