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Changes in NNMT activity may therefore alter the relationship between SAM and S-adenosyl-L-homocysteine and influence methylation-related processes

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It strengthens the connections between cells (tight junctions), directly addressing intestinal permeability ("leaky gut")

Moreover, long Lyme patients are familiar with the Jarisch-Herxheimer Reaction, a potentially intense inflammatory response, which can be elicited by an antibiotic treatment of a persistent borreliosis (138)

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