Although localized mainly in the chloroplasts, the enzyme is also found in cytosol (Edwards et al., 1990), mitochondria and peroxisomes (Jimenez et al., 1997
There are two kinds of forehead lines you might be experiencing
Citrate accumulation increases the production of the main mediators of acute inflammation (nitric oxide, ROS, and prostaglandins), while succinate induces the production of IL-1, a central molecule in inflammation (Icard et al., 2018)
Wang Q, Kong Y, Wu D, Liu J, Jie W, You Q-L, Huang L, Hu J, Chu H-D, Gao F, Hu N-Y, Luo Z-C, Li X, Li S-J, Wu Z, Li Y, Yang J, Gao T (2021) Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
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