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Toxicology 458:152840 Feagan BG, Rochon J, Fedorak RN, Irvine EJ, Wild G, Sutherland L, Steinhart AH, Greenberg GR, Gillies R, Hopkins M (1995) Methotrexate for the treatment of Crohns disease

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To manage these effects effectively, healthcare professionals typically advise patients to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy foods which can exacerbate nausea Stay well hydrated to prevent constipation Eat slowly and chew thoroughly to aid digestion Stop eating when comfortably satisfied rather than feeling overly full Patients should be aware of warning signs requiring medical attention

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Medically reviewed by Kevin Lombardi, M.D., MPH Last update: May 8, 2026 Est