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The key difference between Zepbound and Mounjaro is their approved indications

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Human trials of IGF-1 in PD have not yet been performed, but studies in rat models of PD indicate that it protects dopaminergic neurons and improves behavior

On the other hand, separate Phase 2 trials for leg wounds caused by poor circulation (venous stasis ulcers) confirmed that the protein is safe and shows good healing potential

Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD