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While studies on this population are limited, phentermine use during pregnancy has been associated with a risk of pulmonary hypertension a rare but serious lung disorder

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372,373 Moreover, the -face of Cu I -coordinated His ligand interacts with residues in the second coordination shell including nearly invariant Tyr and Glu residues that are energetically linked to Cu I -mediated allosteric inhibition of DNA binding, suggesting a path for allosteric connectivity

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