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3-[5-(2-Ethyl carbonyl-1-methylvinoxy)1-methyl-1 H-indol-3-yl]but-2-enoic acid ethyl ester, referred to as MIBE, is a synthetic compound that exhibits dual antagonism of ER and GPER by blocking GPER-mediated transactivation of EGFR and inhibiting ERK phosphorylation [279]

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While some of these effects can be beneficial in specific contexts, they create complexity, side effects, and potential contraindications that limit the applicability of growth hormone therapy for individuals seeking primarily fat loss