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A tri-agonist developed by the same company targeting GIP-1R/GIPR/GCGR, retatrutide, demonstrated better weight loss effects in Phase 3 compared to tirzepatide

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TGF- secreted by tumor vascular endothelial cells can induce differentiation of endothelial cells and adjacent fibroblasts into myofibroblasts through both autocrine and paracrine mechanisms (193)

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