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In addition to exacerbating gliosis and inflammation, BBB disruption also leads to oxidative damage such as in ischemia-reperfusion injury where SOD1 deficiency causes exacerbated neuronal damage and infarct volume (Rankin-Gee et al., 2015

(By the way, you can read more about NAC and other options for glutathione supplementation, along with safety guidelines and best practices in What to Avoid When Taking Glutathione)

Bot Stud 54:19 Liu X-M, Ren W-J, Lyu H-Y, Chen C-Y, Pan X-H, Bai L-P, Zhang W, Jiang Z-H, Zhu G-Y (2025) Verbenalinosides A and B, two iridoid-phenylethanoid glycoside conjugates from Verbena officinalis and their hepatoprotective activity

Some peeling on the treated area may also occur

Supporting information S1 Data