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Follow the recommended dosage instructions on the label

Weeks 1-4: 0.25 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 5-8: 0.5 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 9-12: 1.0 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 13-16: 1.7 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Week 17 and beyond: 2.4 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Some providers modify this schedule based on individual tolerance

These GLP-1 drugs can cause dry mouth, often referred to as cottonmouth, but since your brain doesnt signal thirst, you may end up ignoring this sign

doi: 10.1007/s00018-019-03253-8 73 ZhangXCuiYDongLSunMZhangY

We've seen this result in disappointment too many times