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Before a drug candidate can be tested in humans, it needs to pass through a rigorous preparation process that covers several interconnected areas

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Nauck M.A., Meier J.J

Statistical analysis Data were evaluated using Students t test or one-way analysis of variance (ANOVA) with TukeyKramers or Dunnetts post hoc tests

To the best of our knowledge, this is the first demonstration of GLP-1 receptor agonists affecting unstimulated, overnight intake in the absence of food, the first test for antidipsogenic effects of hindbrain application of GLP-1 receptor agonists, and the first test of a central effect (forebrain or hindbrain) of liraglutide on water intake

doi: 10.1007/s00431-009-1058-1