Although they originated as diabetes medications, GLP-1 drugs like Wegovy (semaglutide) and Zepbound (tirzepatide) have proven to be highly effective for weight loss
Mounjaro is given at an initial dose of 2.5 mg and after four weeks, increased to 5 mg
Previously available during FDA shortage declarations, the end of Ozempic shortages in early 2025 eliminated most legal justifications for compounding essentially a copy of the FDA-approved medication
An initial analysis of the FDA adverse event reporting system (FAERS) data demonstrated no consistent trends in DKA with SGLT2i use over time [39], however an alternative cohort study of 50,220 individuals with type 2 diabetes showed the highest risk of DKA shortly after SGLT2i initiation, which subsequently reduced with time [40]
[42] Subsequent analyses have clarified that this early worsening of pre-existing retinopathy is a secondary effect caused by the rapid and robust drop in blood glucose levels, rather than a direct toxic effect of semaglutide on the eyes
