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GLP-1 and analogs increase glucose consumption in mature cells whereas they reduce it in progenitor cells and ADSCs, which can lead to decreased production of ATP and energy deficiency

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Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

other investigations have shown that LFC reduction associated with metabolic disorder improvement and a relative decrease of 30% combined with an improvement in ALT may be predictive of a more active histological response