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The kidneys play a critical role in excreting these agents, with the rate of renal elimination influencing their duration of action and dosing frequency

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Rapid inactivation of these incretin hormones by DPP-4 leads to an insufficient release of insulin following oral glucose intake [31] and many of the physiological signs of T2DM, such as deteriorating glycemic control, are secondary to incretin inactivation by DPP-4

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