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The role of systemic corticosteroids (cortisone) remains controversial

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Nevertheless, further studies are required to elucidate the exact role and underlying molecular mechanisms of the trans-sulphuration pathway in cancer cell death

NRF2-AS showed limited diagnostic performance with an AUC of 0.48 (95% CI: 0.390.57)

Therefore, the pathways regulating ferroptosis susceptibility are more abundant and are considered to have important implications in the pathogenesis, treatment or drug development, and specific studies may be more beneficial for its comprehensive understanding