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For example, lung cancer cell-lines show different sensitivities to doxorubicin in the form of GSH depletion, with A549 and GLC 4 210(S) cells experiencing approximately 50% and 64% GSH depletion after a 12 hour exposure to 70 nM and 5 nM (per million cells) respectively 37

17 The therapeutic approaches of melanoma undergo a dramatic evolution in the past few decades due to the progress in the understanding of melanoma pathogenesis and thereby revolutionary advances of targeted therapies that specifically intervene mutant driver genes and immune checkpoints

10.1186/s13018-019-1242-6 54 PetrovicI.DobricI.DrmicD.SeverM.KlicekR.RadicB.et al (2011)

Loss of ovarian hormones leads to an increase in LDL-C, triglycerides, and a decrease in high density lipoprotein cholesterol (HDL-C) [12]

For male and female patients, the procedure is almost identical