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Changs findings suggest that EX-4 inhibited LPS-induced iNOS expression at protein level, but not at transcriptional level, of iNOS gene via a cAMP/PKA dependent mechanism ( 4 The role of GLP-1/GLP-R in related disease 4.1 Diabetes Diabetes mellitus is characterized by increased inflammation, reflecting innate immune control disorders, and studies have shown a local intestinal intraepithelial lymphocyte (IEL)-GLP-1 receptor (GLP-1R) signaling network that controls the mucosal immune response ( 4.2 Cardiovascular disease The latest research has found that GLP-1R is widely expressed in the cardiovascular system and is involved in intracellular metabolism and signal transduction

In patients with type 2 diabetes mellitus (T2DM), insulin secretion is markedly decreased or absent [2], and GLP-1 receptor agonists (GLP-1 RA) have been shown to improve glycemic control in this population [3, 4]

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Indeed, their effects spaced from induction of citotoxicity and inhibition of metastatic spread, to induction of de-differentiation of TC cells and modulation of TC microenvironment