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While many people associate melasma flare-ups with summer sun exposure, winter is a critical and often overlooked season for managing it effectively

Medical oversight is crucial, particularly to identify infrequent but severe side effects such as pancreatitis or allergic reactions

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Melatonin preserves blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-B pathway

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