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Some individuals using semaglutide have reported gallbladder issues, including gallstones, which may require surgery

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Over the 52-week trial period, the percentage of patients who required glycemic rescue was 8.9% in the TRULICITY 0.75 mg once weekly + metformin and pioglitazone treatment group, 3.2% in the TRULICITY 1.5 mg once weekly + metformin and pioglitazone treatment group, and 8.7% in the exenatide BID + metformin and pioglitazone treatment group

Tell your healthcare provider if your menstrual bleeding changes while you are using birth control and Topiramate