High dose thiamine and Benfotiamine may counter the development of microvascular complications by activation of the reductive pentosephosphate pathway
Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025
Obese patients are at more risk of coming with complications such as hypertension, type two diabetes, raised serum cholesterol levels, stroke, and some types of cancer
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2.3.2 Interleukin 6 To determine the concentration of interleukin 6 (IL-6), serum was centrifuged at room temperature (2,200 x g, 5 min, Centrifuge 5427 R, Eppendorf SE, Hamburg, Germany)