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In a 10-week clinical trial, a daily dose of 20 mg oral semaglutide achieved a steady-state plasma concentration of 30 nM, and when daily dose of oral semaglutide was increased to 40 mg, the semaglutide plasma concentration reached about 60 nM (102), which was over a thousand times higher than the EC50 of semaglutide for GLP-1R activation (95)
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All currently available GLP-1 medications carry the same boxed warning regarding thyroid C-cell tumors based on animal studies, and none have demonstrated superiority or increased risk specifically in patients with autoimmune thyroid disease
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