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PAS article about testing B12 during treatment pernicious-anaemia-society

Neurons undergoing ferroptosis release damage-associated molecular patterns (DAMPs) such as HMGB1, ATP, and lipid peroxidation products, which activate microglia and drive them toward a pro-inflammatory phenotype

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A deficiency can occur if you follow a vegan diet, dont consume enough B12-rich foods, or if you have conditions like pernicious anemia, which impair absorption