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Special Considerations: Regulatory and Ethical Peptides are located within a very niche and dynamic area that requires constant monitoring of the local laws and regulations

Although GLP-1RAs can reduce body weight by 15%25% in controlled settings, real-world adherence is limited, and nearly 70% of patients experience weight regain after discontinuation, raising the risk of long-term pharmacological dependence ( Looking ahead, the future of GLP-1based therapy will depend on addressing safety concerns, improving long-term adherence, and expanding clinical indications

Therefore, coordinately regulating the expression and activity of lipid metabolism enzymes like ACSL4 and LPCAT3 is considered an important intervention strategy from the perspective of reducing the source of ferroptosis substrates (Habaxi et al., 2024)

10 These modifications aim to reduce metabolic risk factors and promote weight loss, decreasing fat accumulation in the liver by creating a negative energy balance and promoting lipolysis, ultimately reducing fibrosis