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A further consideration is the use of acid-suppressing medicines

Constitutively high expression of the histidine biosynthetic pathway contributes to nickel tolerance in hyperaccumulator plants

P., and Baron, J

It does this in 3 main ways: 1) it boosts the release of insulin, which increases the uptake of sugar from the blood to the cells, and inhibits the release of glucagon, which raises the concentration of glucose in the blood 2) it slows stomach emptying and increases fullness and 3) it acts on the brain to reduce appetite and cravings

Patients who tolerate the medication well and stay consistent see steadier results