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After confirming atherosclerotic lesions, the atherosclerotic mice were intravenously injected with different formulations (PBS, Mn/TI@mHSA, and P-Mn/TI@mHSA)

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It appears that a well fitted immune response is required for preventing PAIS development

Improvement of oxygenation in hypoxic tissues, antioxidant effects, suppression of pro-inflammatory cytokines release, and anti-proliferative activity are selected underlying mechanisms of its protective effects [81]