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At lower doses, the increases were proportionally smaller, generally ranging from 2 to 5 beats per minute depending on the specific dose and titration schedule

It also acts on appetite/satiety centres, contributing to reduced food intake

[1] This underscores the importance of maintaining adequate hydration throughout treatment

doi: 10.1177/2515841420950513

Moreover, TZP induced a considerable average decrease of 53-55% in fasting glucagon levels (adjusted for fasting serum glucose), and a 16-24% decrease in HOMA2-IR, calculated with insulin, highlighting its superior effects on insulin sensitivity

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