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none have clinical trial data showing weight reduction at the magnitude of FDA-approved GLP-1 medications

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197 For instance, increased blood urea concentrations can alter the microbiome, resulting in the increased generation of toxic metabolites from the gastrointestinal tract as well as an increased tendency for toxins to cross the gut barrier, which can promote further kidney injury

GLP-1 (glucagon-like peptide-1) is a naturally occurring incretin hormone produced by L-cells in the small intestine in response to food intake

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