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doi: 10.3389/fimmu.2025.1662521 Received 09 July 2025 Revised 04 November 2025 Accepted 12 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Dieter Kabelitz, University of Kiel, Germany Reviewed by George Paltoglou, National and Kapodistrian University of Athens, Greece Anita Vergatti, University of Naples Federico II, Italy Updates Copyright 2025 Li, Xu, Wang, Peng and Liu

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Phenylbutazone was originally developed for chronic pain for conditions such as arthritis but has since been restricted to treating ankylosing spondylitis due to induction of rare but severe blood disorders, including anemia and leukopenia 86