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Moreover, its expression appears to be influenced by metabolic stress, with it being increased in islets from diet-induced obese mice compared to normal weight animals (104), but lower in human islets from diabetic compared to non-diabetic donors (98, 99, 104)

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Endocrine and metabolic outcomes A total of 41 meta-analyses (118 outcomes) evaluated GLP-1 RAs for endocrine and metabolic outcomes (Fig

92 In this mechanism, bacterial GSH is an essential cofactor, and mutants that are defective in GSH biosynthesis cannot inactivate fosfomycin, even though they possess the resistance gene

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